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The STS-107 mission consisted of seven crew members.

Rick D. Husband was the Commander of the flight. He was at the age of 45 and a colonel in the U.S. Air Force. In the role of commander, Husband was to look over the whole mission conduct. This was Husband's second mission in space. His first was in 1999, a 10-day mission in which he was the pilot. Before STS-107 Husband spent more than 235 hours in space, almost 10 days.

William C. McCool was the Pilot of the flight. At the age of 41 he was a commander in the U.S. Navy. McCool was responsible for the experiments of Columbia. STS-107 was McCool's very first space mission.

Michael P. Anderson served as the Payload Commander of the Columbia shuttle. Anderson was a lieutenant colonel in the U.S. Air Force. He was 43 and responsible for the accomplishments of the science mission. Anderson piloted another space mission in 1998. His hours in space recorded up to 211 hours. almost nine days.

David M. Brown was in the position of Mission Specialist 1. He was 46 and a captain in the U.S. Navy, also he was a naval aviator and flight surgeon. This was Brown's first flight into space.

Kalpana Chawla was at the age of 41 and served as the Mission Specialist 2. Also, on the STS-87 in 1997. Chawla spent almost 376 hours, almost 16 days, in space.

Laurel Blair Salton Clark was the Mission Specialist 4 and 41 years old. Clark was the commander in the U.S. Navy and a naval flight surgeon. This was Clark's first spaceflight.

Ilan Ramon was 48 and in the position of the Payload Specialist 1. Ramon was a colonel in the Israel Air Force. He was the only Payload Specialist on the Columbia shuttle. The STS-107 was Ramon's first spaceflight.