1) Nolan Ryan - 5,714 Strikeouts

2) Steve Carlton - 4,136 Strikeouts

3) Bert Blyleven - 3,701 Strikeouts

4) Tom Seaver - 3,640 Strikeouts

5) Don Sutton - 3,574 Strikeouts

6) Gaylord Perry - 3,534 Strikeouts

7) Walter Johnson - 3,508 Strikeouts

8) Roger Clemens - 3,429 Strikeouts

9) Phil Niekro - 3,342 Strikeouts

10) Ferguson Jenkins - 3,192 Strikeouts