1) Ty Cobb - 2,245 Runs

2) Babe Ruth - 2,174 Runs

2) Hank Aaron - 2,174 Runs

4) Pete Rose - 2,165 Runs

5) Ricky Henderson - 2,067 Runs

6) Willie Mays - 2,062 Runs

7) Stan Musial - 1,949 Runs

8) Lou Gehrig - 1,888 Runs

9) Tris Speaker - 1,881 Runs

10) Mel Ott - 1,859 Runs