1) Cy Young - 313 Losses

2) Pud Calvin - 300 Losses

3) Nolan Ryan - 292 Losses

4) Walter Johnson - 279 Losses

5) Phil Niekro - 274 Losses

6) Gaylord Perry - 265 Losses

7) Don Sutton - 256 Losses

8) Jack Powel - 254 Losses

9) Eppa Nixley - 251 Losses

10) Brent Blyleven - 250 Losses