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Addiction - From Craving to Recovery

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There are 100 regional consortia of campus drug prevention programs in the United States.

Addiction

Cocaine

Cocaine

In the so called war against drugs, cocaine is considered to be the top contender and the top priority for the eradication of addictive and abused substances in the United States. From 1978 to 1987, the United States experienced the largest cocaine epidemic, producing widely publicized and highly visible antisocial and criminal activities related to the effects of this substance of abuse. As recently as the 1980s, cocaine was believed to not cause dependency since it did not cause gross withdrawal effects such as those experienced by abusers of alcohol and narcotics. In 1982, to exemplify this perception toward cocaine, Scientific American stated that cocaine was "no more habit forming than potato chips." However, this perception of the drug is clearly false as cocaine is so highly addictive that it is readily self administered by human as well as laboratory animals. In fact, surveys claim that 1.5 million Americans are chronic cocaine users. Cocaine is derived from the coca plant, which is primarily grown in the Andean countries. America's problem with cocaine addiction has had profound effects on several South American countries, such as Bolivia, which according to National Geographic, can bring in between $500 million to $1 billion from coca plant exports annually. In U.S. terms this number is very small, but for a poor country like Bolivia this money can mean the difference between life and death for many impoverished families. The fact that 1 kilogram of cocaine can bring a farmer $1000 combined with the traditional thought that cocaine is the desired substance in Latin American countries, it is difficult to persuade farmers to change crops in these countries. Cocaine is one of several ingredients from the leaves of Erythroxylon coca. Its leaves are harvest two to three times a year, processed into a paste in clandestine labs to form a pure, white hydrochloride salt. This form of purified cocaine is often adulterated, in which contaminating substances are mixed in to dilute the drugs. The adverse responses to administering street cocaine are sometimes caused by the additives, rather than the cocaine itself. Cocaine abusers can use different administrative methods such as oral administration, inhalation into the nasal passageways, injection intravenously or smoking the drug all of which in response produce different levels of potent effects on the individual with oral administration causing the least effects. Sometimes cocaine is "freebased" or converted into its alkaline form to reduce the impurities of processing for the purpose of smoking. This is the case for "Crack" or an already processed and inexpensive "freebased" cocaine. Modern technology has allowed scientists to better understand how the different vital systems of the body are effected by cocaine. Cocaine profoundly effects the body through enhanced activation of catecholamine and serotonin transmitters, blocking the uptake and inactivation of the these substances following their release from neurons, consequently prolonging the effects of these transmitters. The combination of cocaine's effects on these transmitters result in CNS stimulation.

Cocaine

Central Nervous System

Cocaine is often used by individuals suffering from severe depression or the negative effects of schizophrenia, however the abuse potential and the short-term action of the drug make it an unsatisfying treatment for depression. High doses of cocaine, based on the form of administration, can create feelings of euphoria, enhance the sense of strength, energy and performance of the body, all of which encourage continual use and dependence. Cocaine addicts identify their experiences as two stage phenomena. First comes the "rush," characterized by increased heart rate, sweating and feelings of "being out of control." This is usually followed by the second stage, which is a combination of feelings of sociability, euphoria and self-confidence. However, the exhilaration and confidence caused by cocaine can turn into irritable restlessness and confused hyperactivity, especially in high doses when an individual's personality may resemble paranoid schizophrenia. After even 12 minutes of administration, drug craving is evident as certain regions of the limbic system become associated with these drugs. Other side effects of cocaine usage include headaches, temporary loss of consciousness, seizures and death.

Cardiovascular System

Cocaine can profoundly effect the cardiovascular system as it enhances the sympathetic nervous system, increases levels of adrenaline in the body, and causes vasoconstriction. The effects of cocaine cause the heart to beat harder and faster, while the veins are constricting, which in turn limits blood flow and raises blood pressure. Such a combination can lead to severe heart arrhythmia, an irregular contraction pattern, or heart attack. Depending of the form of administration, cocaine can also damage other tissues in the body, prompting a stroke, lung damage in those that smoke it, destruction of nasal cartilage for those that snort it and injury to the gastrointestinal tract.

Local Anesthetic Effect

Cocaine is a preferred local anesthetic for minor pharyngeal surgery due to its vasoconstriction and topical, local numbing effects. Cocaine remains relatively safe if applied topically, as along as the dosage is small enough that sensitive people due not experience CNS stimulation, toxic psychosis from cocaine entering the bloodstream and even causing death. Withdrawal symptoms resulting from cocaine use have always been a question until recently after an epidemic of high instances of chronic usage has lead to the discovery that the CNS develops tolerance to cocaine and that cocaine usage is less likely to stop voluntarily than with any other illicit drug. Research has concluded that after rigorous study, the extent of cocaine withdrawal if proportional to the duration and intensity of use. Though the physical withdrawal symptoms are relatively minor compared to CNS depressants, a cocaine user is 60 times more likely to commit suicide within the initial hours of usage than a normal person. Short-term withdrawal symptoms also include sleep abnormalities, craving for the drug, agitation, and anhedonia (the inability to experience pleasure). Long-term withdrawal effects include a return to normal pleasures, accompanied by mood swings, and occasional craving triggered by cues in the surroundings. According to the American Psychiatric Association, cocaine dependency is classified as a psychiatric disorder and no one treatment technique has been found to be significantly superior to other s or universally effects because treatment programs often do not take into account the patients that drop out of treatment when they are assessed. However, most treatments focus on relieving craving rather than extinguishing it. The major differences in cocaine treatment programs are whether outpatient or inpatient status is appropriate, which drugs and what dosages should be used to treat patients during various stages of abstinence, and what length of time the patient should be isolated from cocaine-accessible environments. The most important thing is that patients should acquire treatment according to their individual needs. One of the biggest problems of cocaine use has to do with miscarriages, premature infants and cocaine babies or children exposed to cocaine while in the womb. The United States alone spend over $1 billion dollars annually for maternal care of cocaine using women during their pregnancies, however most of these babies a born prematurely with birth defects and are abandoned by their mothers and left to the welfare system for care.

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