| Notes: Mutations et al. |
Transcription and Translation: Mutations
Point Mutations are mutations of 1 nucleotide
The theory goes like this:
if the mutation adversely affects phenotype, it is a genetic disorder or hereditary disease.
Types of Mutations
base-pair substitutions: replace one nucleotide and its complementary portion with another pair
silent mutation: base pair change may transform a codon into one that still codes for the same amino acid
missense mutation: still code for an amino acid but a different one
and thus make sense but not the "right" sense
if it altered a crucial area (active site for example) would = even
more interesting
nonsense mutation: change codes for a stop codon
insertion and deletion: create frameshift changes
Mutagens
Hermann Muller found that X-rays increase genetic changes
(example: thymine dimers) that affect DNA replication, repair, or
recombination.
Next: "Viruses."