| Notes: Matthew Meselson and Franklin Stahl |

HYPOTHESIZED MODELS OF DNA
REPLICATION
Meselson and Stahl cultured bacteria on heavy-nitrogen (15N), transferred the same bacteria to light-nitrogen (14N) and centrifuged half after 20 and half 40 minutes (see below chart) to isolate the DNA for inspection.
Based on these principles light DNA will rise, heavy DNA will sink, moderate DNA will be in the middle.
Time |
Conservative model |
Semi-conservative model |
Dispersive model |
| After 20 minutes | ![]() |
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| After 40 minutes | ![]() |
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Next: "DNA Replication."