333 BCE Alexander the Great conquers Egypt

 
332 BCE Alexander founds Alexandria

 
304-285 BCE Ptolemy I Soter I rulers

285-246 BCE Ptolemy II Philadelphus rules

 
246-221 BCE Ptolemy III Euergetes rules

 
221 BCE Great Wall of China completed

 
221-205 BCE Ptolemy IV Philopator rules

 
205-181 BCE Ptolemy V Epiphanes rules

 
181-170 BCE Ptolemy VI Philomaetor rules

 
170-145 BCE Ptolemy VIII Physcon rules

 
145 BCE Ptolemy VII Neos Philopator rules

 
116-107 & 88-80 BCE Ptolemy IX Lathyrus rules

 
107-88 BCE

Ptolemy X Alexander I rules

80 BCE Ptolemy XI Alexander II rules

80-58 & 55- 51 BCE Ptolemy XII Neos Dionysos rules

 
58-57 BCE Cleopatra VI Tryphaena rules

 
57-55 BCE Berenice IV rules

 
51-49 & 48-30 BCE Cleopatra VII Philopator rules  

 
51-47 BCE Ptolemy XIII reigns with Cleopatra VII

47-44 BCE

Ptolemy XIV Philopator Philadelphe rules with Cleopatra VII  

 
48 BCE Ptolemy murdered by Septimus  

47-44 BCE Cleopatra and Ptolemy XIV rule

44 BCE Julius Caesar murdered at the Senate

44-30 BCE Cleopatra and Ptolemy XV Caesarion rule

30 BCE Cleopatra committed suicide