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Monoclonal Antibodies Technique for producing monoclonal antibodies enables providing limitless amount of needed antibody. It is based on fusion of cancer B cell with a normal one. Such hybrid cells (hybrodomas) divide quickly (characteristic feature of cancer cells) and produce specific antibody. This technique was elaborated by dr Caesar Milstein and dr George Kohler (Laboratory for Molecular Biology, Medical Research Council, Cambridge, London). It is possible to produce antibodies against certain antigen. Injection of antigens into for example mice body leads to antibody production in their organism. B cells producing the antibody can be then obtained from mice and the further production takes place in laboratory. Antibodies always bond only with specific protein. This feature enables using them to find and act toward chosen cells. Investigations are being made to use monoclonal antibodies for example in cancer and autoimmune diseases therapy and in transplantology. In each case the idea is to identify and destroy certain cells. |
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© team C003548, made for ThinkQuest 2000 |