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About 200 children are diagnosed with retinoblastoma (eye cancer) each year in the United States. This cancer affects about one out of every 20,000 children, accounting for 3.1% of all childhood cancers. Most children with retinoblastoma are under four years of age. About 75% of children with retinoblastoma have a tumor in one eye. In about 25% of cases, both eyes are affected.