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Human Genome Project

tabThe Human Genome Project is one of the most enterprising and challenging aspects of modern genetic research. Funded primarily by the US Government, this project was created to map and sequence the entire human genome--that is, to locate every gene on every human chromosome. Although this may sound rather basic, the enormity of it emerges when one realizes just how lengthy the human genome actually is. It is estimated that anywhere from 100,000 to 300,000 genes exist! And scientists not only plan to map the genes, but also intend to sequence the 3 billion DNA amino acid “building blocks” that make each gene! It would take thirteen full-volumed encyclopedia sets or 200 Manhattan phone books to equal the amount of genetic information the project scientists plan to organize. It is, therefore, easy to understand why this is a national effort.

Scientists

Scientists reading DNA sequencing gel
Courtesy USDA ARS

Francis Crick elucidated the structure of DNA with James Watson in 1953 (see Watson JD, Crick FHC (1953) Molecular Structure of Nucleic Acis. Nature 171:737-738 and the follow up article in May the same year Watson JD, Crick FHC (1953) Genetical Implications of the Structure of deoxyribonucleic acid. Nature 171 964-964). The Department of Energy is also involved along with foreign countries as research and money come from Japan, the United Kingdom, and and other technologically advanced nations. Research and data storage laboratories called Genome Centers are scattered throughout the US from Berkeley, California to Los Alamos. Many colleges and universities are also involved including Stanford University, Baylor College of Medicine, Washington University, and the Universities of Utah, Texas, Washington, and Wisconsin.

Gene

A gene is a segment of DNA


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