1938: Spemann conceives cloning.

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Scientist Profile:
Hans Spemann

Web Link:
Biography of Hans Spemann

Hans Spemann published the landmark results of his 1928 primitive nuclear transfer experiment involving salamander embryos in his 1938 book "Embryonic Development and Induction." In this book, Spemann claimed the next logical step for research to be the "fantastical experiment," as he called it, of cloning organisms by extracting the nucleus of a differentiated cell and inserting it into an enucleated fertilized egg. Also in the book, Spemann proposed the exciting idea of cloning from adult cell nuclei. However, Spemann was unable to technically devise a way to attempt any such experiments during his lifetime. No one succeeded in doing so until Robert Briggs and Thomas J. King cloned tadpoles in 1952. Without knowing it, Briggs' and King's method of cloning using the nuclear transfer method was highly similar to Spemann's 1938 "fantastical experiment" proposal.

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