
If genetic engineering is defined as changing an organism's DNA to make it more beneficial, genetic engineering has been going on for a very, very long time in the form of selective breeding. However, actually going into a cell and changing its genome by inserting or removing DNA is a very new technology.
Ancient History
Selective breeding has been
going on for countless generations. In fact, it is even mentioned
in the Bible (Genesis 30:25 - 43). In the account, Jacob was employed
as a shepherd under his father-in-law Laban. Instead of receiving
wages, Jacob received the black, streaked, and spotted sheep, and Laban
kept all the white sheep. Jacob craftily arranged for his black sheep
to mate with Laban's white sheep, producing streaked and spotted sheep.
Jacob did so well with this scheme that Laban's family began to get mad
at Jacob, and he eventually had to leave.
Difficulties
Selective
breeding is effective enough if the goal is to maintain or gradually
improve a group of animals. Over the decades, selective breeding
has brought us improved strains of cattle and specialized breeds of dogs.
However, these advances have taken hundreds of years to effect. In
addition to the time concerns, it is often impossible to know which traits
will be transferred to the offspring.
Limits
Selective breeding is a
long, tedious process that has its limits. It is impossible through
selective breeding to mix traits from two totally different species.
If a junkyard owner wanted a guard dog that could squirt ink like an octopus,
he would be unable to create such an animal. It is physically impossible,
because the genetics of life are such that traits from two different organisms
cannot be mixed. That is where genetic engineering comes in.
The Progress
Modern genetic engineering
began in 1973 when Herbert Boyer and Stanley Cohen used enzymes to cut
a bacteria plasmid
and insert another strand of DNA in the gap. Both bits of DNA were
from the same type of bacteria, but this milestone, the invention of recombinant
DNA technology, offered a window into the previously impossible -- the
mixing of traits between totally dissimilar organisms. To prove that
this was possible, Cohen and Boyer used the same process to put a bit of
frog DNA into a bacteria.
Since 1973, this technology
has been made more controllable by the discovery of new enzymes to cut
the DNA differently and by mapping the genetic code of different organisms.
Now that we have a better idea of what part of the genetic code does what,
we have been able to make bacteria that produce human insulin for diabetics
(previously came from livestock), as well as EPO for people on kidney dialysis
(previously came from urine of people in third world countries with ringworm).
In 1990, a young child with
an extremely poor immune system recieved genetic therapy. Some of
her white blood cells were genetically manipulated and re-introduced into
her bloodstream while she watched Sesame Street. These new cells
have taken over for the original, weak white cells, and her immune system
now works properly. Although relatively few people have had their
cells genetically altered, these advances have made the prospect of mainstream
genetic medicine seem more likely.
The Promise
Genetic engineers hope that
with enough knowledge and experimentation, it will be possible in the future
to create "made-to-order" organisms. This will lead to new innovations,
possibly including custom bacteria to clean up chemical spills, or fruit
trees that bear different kinds of fruit in different seasons. Any
trait occurring in nature can theoretically be mixed with any other to
form a totally new organism that would not otherwise occur in nature.
Current Status
As of late summer of 1998,
scientists are able to add simple traits to organisms. They cannot
create custom-made animals. They cannot always predict how traits
will interact. Before phenomenally new advances can be made, scientists
have to learn how to affect cells' DNA with pin-point accuracy, without
affecting other traits. Advances like genetic correction for nearsightedness
are a long way off. The power of science is limited to knowledge
about genetics, gene locations, and trait interactions, but as knowledge
grows, so will scientists' abilities to manipulate life.