Cystic Fibrosis (CF) is an inherited disorder which affects many functions of the body, such as breathing, digestion, and reproduction. It is a lifelong disorder which usually gets more severe by age and both male and females can have it.
In CF, the glands which produce mucus, saliva and intestinal fluids do not work properly and people with Cystic Fibrosis have secretions which are thick and sticky rather than thin and watery. This can cause breathing problems, lung damage, improper growth and weight gain, digestive problems, and respiratory problems, but people with Cystic Fibrosis have normal intelligence. Cystic Fibrosis is diagnosed by making a sweat test to look for high levels of salt. Genetic testing can also be done. Although there is no cure for Cystic Fibrosis, there are treatments which can improve the lives of people with the disorder by helping to control their symptoms.
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Cystic Fibrosis is caused by
a pain of genes that are not working properly and have a mutation. A person with the
disorder receives one of the Cystic Fibrosis genes from each parent. The parents of a
child with Cystic Fibrosis are carriers, which means they do not have the disorder. They
have one working copy of the gene and one nonworking copy of the gene. Two carrier parents
have a 25% chance of having a child who is a noncarrier of CF(unaffected), a 50% chance of
having a child who carries the gene (unaffected), and a 25% chance of having a child who
is affected by CF.
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Not only is Cystic Fibrosis a genetic disorder, but a persons ethnic background can also increase a persons chance of being a carrier of CF. The table below shows the risk of being a Cystic Fibrosis carrier based on your ethnic background, when there is no family history of CF.
| Individual | Carrier Risk | Carrier Probability |
| Caucasian | 1 in 25 | 4% |
| Ashkenazi Jew | 1 in 29 | 3.4% |
| Hispanic | 1 in 48 | 2.1% |
| African American | 1 in 65 | 1.5% |
| Asian | 1 in 150 | 0.7% |
HEMOPHILIA | CYSTIC FIBROSIS | HUNTINGTON'S DISEASE | SICKLE-CELL ANEMIA | CANCER | QUIZ