Dr. Doom 

Dr. Doom has been a phenomenon since 1962. He is the antagonist in The Fantastic Four series and he has always tried to destroy them to obtain world domination. Dr. doom has been close to dying many times, but always finds a way to overcome death.

Victor Von Doom was a troubled kid: his mother and father were both part of a nomadic group and his mother died after causing a lot of damage to her tribe. When his mother died, he decided to get more involved in science and sorcery. Later on, the Dean Science University gave him a scholarship. 

When he went to Dean Science University, where he met Reed Richards (who later on would become Mr. Fantastic).  Doom was humiliated by Reed and eventually expelled from the University. He decided to come to the United States and promised to carry out his revenge on Reed. Though he has not completed his revengeful wrath, he has caused the Fantastic Four tremendous damage and difficulties.

Green Goblin:
Green Goblin is Spider-Man’s enemy for many years and has tried to get Spider-Man to meet his demise. The Green Goblin has not been able to kill Spider-Man, but in some way he has succeeded in hurting Spider-Man. But how did he get from being an industrial worker to a villain?
The Green Goblin’s real name is Norman Osborn. His wife died a year after giving birth and he was left alone to raise his only son, Harry. As Harry was growing up, Norman became more distant and was more involved with his experiments. One day he decided to test an experiment on himself and caused him to receive accidental super powers. Around this time Spider-Man was the hero that everyone loved and admired, he became jealous and decided to stop Spider-Man and finish him off. That is where it all began. All of the Goblin’s hatred and animosity went towards Spider-Man. He fought him on multiple occasions, but was never successful. One way he did hurt him was by killing Gwen Stacy, Spider-Man’s girlfriend. Green Goblin was considered dead for many years after this encounter, but he later returned to try and complete his goal: to destroy Spider-Man.