By the late 9th century, the Abbasid caliphate began to fracture as various regions gained increasing levels of autonomy. Across North Africa, Persia, and Central Asia emirates formed as provinces broke away. The monolithic Arab empire gave way to a more religiously homogenized Muslim world where the Shia Fatimids contested even the religious authority of the caliphate. By 1055 the Seljuq Turks had eliminated the Abbasids as a military power, nevertheless they continued to respect the caliph's titular authority. During this time expansion of the Muslim world continued, by both conquest and peaceful proselytism even as both Islam and Muslim trade networks were extending into sub-Saharan West Africa, Central Asia, Volga Bulgaria and the Malay archipelago.

Artistic depiction of the Battle of Hattin in 1187, where Jerusalem was recaptured by Saladin's Ayyubid forces

In the early 16th century, the Shi'ite Safavid dynasty assumed control in Persia and established Shi'a Islam as an official religion there, and despite periodic setbacks, the Safavids remained powerful for two centuries. Meanwhile, Mamluk Egypt fell to the Ottomans in 1517, who then launched a European campaign which reached as far as the gates of Vienna in 1529. After the invasion of Persia, and sack of Baghdad by the Mongols in 1258, Delhi became the most important cultural centre of the Muslim east. Many Islamic dynasties ruled parts of the Indian subcontinent starting from the 12th century. The prominent ones include the Delhi Sultanate (1206–1526) and the Mughal empire (1526–1857). These empires helped in the spread of Islam in South Asia. but by the mid-18th century the British empire had ended the Mughal dynasty.