The severity of hemophilia depends mostly on the size of the mutation in the gene.  A minor mutation might be a different letter in the DNA code; whereas, a major mutation might be a whole series of letters being changed or switched around.

DNA
red blood cell
a DNA code

If a father and mother both have the hemophilia trait, it is possible that a girl may have hemophilia just as any boy could.  This is because both the X chromosomes could carry the gene, so the girl would have a mutated clotting factor. 

an x chromosome

Girls may contract hemophilia, but they are most likely to be a carrier.  This means that though a girl has the mutation on her gene, her clotting factor works properly because her body can use her other X chromosome with its clotting factor functioning properly.  However, she can still pass hemophilia on to her children.

Father XhY (XY)       Mother XhX (XX)
Female XXh (XhX)

Some examples of how the hemophilia gene can be passed on from one or two parents:
Hemophilia: What is it? Continued...


The human skull is made up of 29 different bones.


"Take care of your body.  It's the only place you have to live."

-Jim Rohn

Medical Quotes
External Links
National Heart, Lung, and Blood Institute

Canadian Hemophilia Society

Did You Know?