The Roslin Technique, a variation of the SCNT technique, was developed by researchers at the Roslin Institute in Scotland. It was with this technique that Dolly the sheep was cloned. Other animals had been cloned before her, but she was the first mammal cloned from an adult cell, rather than embryonic. It was months after the birth of Dolly that cloning sparked public interest. This technique involves egg and somatic cells with their nuclei intact, as opposed to enucleated cells in SCNT.

Somatic cells are allowed to grow and divide, and then they are deprived of nutrients to force the cells into a suspended or dormant stage. Then, an egg cell that has had its nucleus removed is placed in proximity to a somatic cell. Scientists will then shock both cells with an electrical pulse. If all goes well, the cells fuse and the egg is allowed to develop into an embryo. This embryo is then implanted into a surrogate.